Date of Tips: 21/11/2025
Disclaimer The odds for these selections were correct at the time of publishing (10:46 21/11/2025) but may have changed since. Please check the latest price before placing your bet.
Manchester City FC
v Bayer 04 Leverkusen 
Etihad Stadium
UEFA Champions League LEAGUE_STAGE 
25-11-2025 20:00
Man City Form
Leverkusen Form
Manchester City vs Bayer Leverkusen prediction talk starts heating up as these two finally meet on Tuesday, 25th November at 20:00 BST, with the Etihad Stadium hosting a Champions League night that feels a bit different. You’ve got Pep Guardiola’s Manchester City on one side, clicking into gear and fresh off a confident win, and Kasper Hjulmand’s Bayer Leverkusen arriving with goals in their boots and nothing to lose. So, if you’re looking for early thoughts on how this plays out, the Manchester City vs Bayer Leverkusen prediction naturally leans toward a high-energy, attacking game with chances at both ends.
Manchester City come into the match mostly healthy, but Mateo Kovacic remains out with an ankle injury. Pep Guardiola will also be without Kalvin Phillips, who is suspended. Other than that, he has a full squad available and plenty of in-form forwards to pick from.
Leverkusen, meanwhile, travel without captain Robert Andrich, who continues a two-match ban. You also noted absences for Exequiel Palacios and Equi Fernandez, while there’s a possibility that Axel Tape-Kobrissa, Lucas Vazquez, and Nathan Tella could return. What we do know is that Leverkusen’s main attacking threats—Patrik Schick, Jonas Hofmann, Ernest Poku, and Ibrahim Maza—are all available after big contributions in their last match.
G Donnarumma
M Nunes – R Alves Dias – J Gvardiol – N O’Reilly
B Silva – N Gonzalez Iglesias – P Foden
M Cherki – E Haaland – J Doku
Subs available: Trafford, Reijnders, Stones, Aké, Marmoush, Ait Nouri, Savinho, Bobb, Lewis
M Flekken
R Andrich – L Bade – E Tapsoba – Arthur
I Maza – A García
A Grimaldo – J Hofmann – E Poku
P Schick
Subs available: Blaswich, Quansah, Belocian, Tillman, Echeverri, Kofane, Sarco, Seghir, Terrier
Manchester City come into this one in strong form, having beaten Liverpool 3-0 with goals from Erling Haaland, González, and Jérémy Doku. They only allowed one shot on target, which gives you an idea of how organised they’ve been defensively in recent matches. Across their last six outings, they’ve conceded just four goals, and their attack keeps finding ways to produce.
Leverkusen also land in Manchester flying high after a 6-0 Bundesliga win where Schick, Hofmann, Poku, and Maza all got on the scoresheet. Their recent games have been full of goals—27 in their last six matches—so they’re not coming to sit back.
City have been strong at home, steady at the back, and firing up front. Haaland continues to score, the structure looks solid, and Guardiola’s team tends to control matches at the Etihad.
Leverkusen’s recent matches have been chaotic and full of goals. They have attacking players in form, and City’s style often leaves space for counter-attacks. You wouldn’t be surprised to see both sides score.
City’s Champions League run includes multiple games with two or more goals scored. Leverkusen’s average goal count in recent fixtures suggests the match could open up quickly.
Leverkusen have enough attacking quality to trouble anyone, and you can absolutely see them creating at least one clear chance. But over 90 minutes at the Etihad, City tend to control the flow, the tempo, and the big moments. The prediction leans toward a Manchester City win—but not without resistance.
Match Prediction: Man City to win. Bet with bet365.
A realistic scoreline looks something like 2–1 Manchester City. City’s forwards are reliable, Haaland is in rhythm, and the wide players keep stretching teams. Leverkusen, though, have shown they can score against anyone and should create enough danger to get one.
Correct Score Prediction: Manchester City 2–1 Bayer Leverkusen. Bet with bet365.
If you’re leaning towards goals, the evidence points upward.
City have scored two or more in multiple Champions League games, and Leverkusen’s recent matches have been high scoring. Over 2.5 and even something higher feels justified based purely on current attacking trends.
Over/Under Prediction: Over 2.5 Goals. Bet with bet365.
A safe, simple combination based only on your info could look like:
– Manchester City to win
– Erling Haaland to score
– Over 2 goals in the match
Bet Builder Tip: Manchester City to win, Erling Haaland to score, over 2.5 goals. Bet with bet365.
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Visit our football previews & predictions page for more betting tips on upcoming matches.
Manchester City look more likely, especially at home.
Leverkusen’s recent attacking form suggests they have a strong chance of finding the net.
Erling Haaland is the standout name.
Yes. Both teams’ recent performances point toward an open match.
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